Archaeoinformatics - Data Science

MA: Evaluating Protein Networks – Puzzling the Biological Secret Behind the Data

Contact: Christian Beth, M.Sc.

Example Protein Network

Protein interaction and function overview (figure taken from [1])

The development of novel metallic biomaterials as implants for medical application requires an attentive elucidation of impaired or improved physiological processes and responses. Therefore, we establish in vitro models to analyse cellular reactions on different biological levels. Fundamental information can be obtained from analysing the variations in the protein synthesis. Functional interactions, relationships, and correlations between the tremendous diverse proteins lead to multifaceted and complex networks. Structured data science will help to elucidate these networks and contribute to define sensitive cellular processes and regularities. The main task will be the classification of big data sets in order to read out principles and pattern. This work will be based on the creative embedding of biological data into mathematical models.

[1] Understanding Protein Networks Using Vester's Sensitivity Model, Moreno, LA et al. in IEEE/ACM Transactions on Computational Biology and Bioinformatics, vol. 17, no. 4, pp. 1440-1450, (2020)